대학원소개

교수진

김세훈

직위 교수
TEL 02-958-5924|02-3290-5965
Fax
E-mail sehoonkim@kist.re.kr
Office KIST L1102 / 고려대학교 KU R&D 센터 433호
연구실 Biophotonics and Nanomedicine Laboratory

세부전공

Biophotonics / biophotonic molecules, polymers, nanomaterials
Biosensor / chemosensor
Bioimaging / molecular imaging
Nanomedicine / photomedicine / theragnosis

학력

1998.03 ~ 2002.02Ph.D. in Materials Science and Engineering, Seoul National University
1996.03 ~ 1998.02M.S. in Fiber and Polymer Science, Seoul National University
1992.03 ~ 1996.02B.S. in Fiber and Polymer Science, Seoul National University

경력

2020.09 ~ Head of Center for Theragnosis, Korea Institute of Science and Technology
2017.09 ~ KU-KIST Graduate School of Converging Science and Technology, Korea University
2008.03 ~ Senior/principal research scientist, Center for Theragnosis, Korea Institute of Science and Technology
2004.04 ~ 2008.02Postdoctoral associate, Institute for Lasers, Photonics and Biophotonics, State University of New York (SUNY) at Buffalo
2002.03 ~ 2004.03Postdoctoral associate, School of Materials Science and Engineering, Seoul National University

수상

[국내]2014
KIST 미래과학인재상(박원희연구상)
[국외]2012
일본고분자학회 Asia Excellence
[국내]2011
기초기술연구회 우수신진연구
[국내]2004
International postdoctoral research fellowship, National Research Foundation

주요논문

2020

Cho, H.-J.; Park, S.-J.; Jung, W. H.; Cho, Y.; Ahn, D. J.*; Lee, Y.-S.*; Kim, S.* “Injectable Single-Component Peptide Depot: Autonomously Rechargeable Tumor Photosensitization for Repeated Photodynamic Therapy”, ACS Nano 2020, 14, 15793-15805.
Kim, J.; Jeon, S.; Kang, S. J.; Kim, K. R.; Thai, HBD; Lee, S.; Kim, S.; Lee, Y. S.; Ahn, D. R. “Lung-targeted delivery of TGF-beta antisense oligonucleotides to treat pulmonary fibrosis”, J. Control. Release 2020, 322, 108-121.
Jeena, M. T.; Lee, S.; Kim, S.*; Ryu, J.-H.* “Intra-Mitochondrial Self-Assembly of Peptides Overcomes Intracellular Enzymatic Degradation of L-peptides”, Chem. Commun. 2020, 56, 6265-6268.
Kim, D.; Lee, Y.-D.; Jo, S.; Kim, S.*; Lee, T. S.* “Detection and imaging of cathepsin L in cancer cells using the aggregation ofconjugated polymer dots and magnetic nanoparticles”, Sensors & Actuators: B. Chemical 2020, 307, 127641.
Choi, E.; Lim, D.-K.; Kim, S.* “Hydrolytic surface erosion of mesoporous silica nanoparticles for efficient intracellular delivery of cytochrome c”, J. Colloid Interface Sci. 2020, 560, 416-425.
Choi, E.; Lim, D.-K.; Kim, S.* “Calcium-doped mesoporous silica nanoparticles as a lysosomolytic nanocarrier for amine-free loading and cytosolic delivery of siRNA”, J. Ind. Eng. Chem. 2020, 81, 71-80.

2019

Jeena, M. T.; Jeong, K.; Go, E. M.; Lee, S.; Jin, S.; Bang, W.-Y.; Lee, E.; Kwak, S. K.; Kim, S.*; Ryu, J.-H.* “Heterochiral Assembly of Amphiphilic Peptides Inside the Mitochondria for Supramolecular Cancer Therapeutics”, ACS Nano 2019, 13, 11022-11033.
Kim, D.; Jeong, K.; Park, H.; Kwon, J. E.; Kim, S.; Park, S. Y.* “Dual-Color Fluorescent Nanoparticles Showing Perfect Color-Specific Photoswitching for Bioimaging and Super-Resolution Microscopy”, Nat. Commun. 2019, 10, 3089.
Li, X.; Jeong, K.; Lee, Y.; Guo, T.; Lee, D.; Park, J.; Kwon, N.; Na, J.-H.; Hong, S. K.; Cha, S.-S.; 2 Huang, J.-D.; Choi, S.; Kim, S.*; Yoon, J.* “Water-soluble phthalocyanines selectively bind to albumin dimers: A green approach toward enhancing tumor-targeted photodynamic therapy”, Theranostics 2019, 9, 6412-6423.
Cho, H.-J.; Park, S.-J.; Lee, Y.-S.; Kim, S.* “Theranostic iRGD peptide containing cisplatin prodrug: dual-cargo tumor penetration for improved imaging and therapy”, J. Control. Release 2019, 300, 73-80.
Choi, E.; Lee, J.; Kwon, I. C.; Lim, D.-K.; Kim, S.* “Cumulative Directional Calcium Gluing between Phosphate and Silicate: A Facile, Robust and Biocompatible Strategy for siRNA Delivery with Amine-Free Non-Positive Vector”, Biomaterials 2019, 209, 126-137.
Heo, J.; Lim, C.-K.; Min, H. S.; Lee, K. E.; Jeong, K.; Seo, Y. H.; Lee, Y.-D.; Yhee, J. Y.; Kim, K.; Kwon, I. C.; Park, S. Y.; Kim, S.* “Rational Design of Inflammation-Responsive Inflatable Nanogels for Ultrasound Molecular Imaging”, Chem. Mater. 2019, 31, 2905-2912.
Choi, E.; Kim, S.* “Surface pH Buffering to Promote Degradation of Mesoporous Silica Nanoparticles under a Physiological Condition”, J. Colloid Interface Sci. 2019, 533, 463-470.

2018

Eom, T.; Yoo, W.; Kim, S.*; Khan, A.* “Biologically Activatable Azobenzene Polymers Targeted at Drug Delivery and Imaging Applications”, Biomaterials 2018, 185, 333-347.
Park, J.; Choi, E.; Shin, S.; Lim, S.; Kim, D.; Baek, S.; Lee, K. P.; Lee, J. J.; Lee, B. H.; Kim, B.; Jeong, K.*; Baik, J.-H.; Kim, Y. K.*; Kim, S.* “Nootropic nanocomplex with enhanced blood-brain barrier permeability for treatment of traumatic brain injury-associated neurodegeneration”, J. Control. Release 2018, 284, 152-159.
Hwang, J. H.; Lee, D.; Yeo, H.; Rao, J.; Zhu, Z.; Shin, J.; Jeong, K.; Kim, S.; Jung, H. W.; Khan, A.* “Proton Transfer Hydrogels: Versatility and Applications”, J. Am. Chem. Soc. 2018, 140, 6700-6709.
Choi, E.; Yoo, W.; Park, J. H.; Kim, S.* “Simultaneous Delivery of Electrostatically Complexed Multiple Gene-Targeting siRNAs and an Anticancer Drug for Synergistically Enhanced Treatment of Prostate Cancer”, Mol. Parm. 2018, 15, 3777-3785.
Lee, S.-C.; Heo, J.; Woo, H. C.; Lee, J.-A.; Seo, Y. H.; Lee, C.-L.*; Kim, S.*; Kwon, O.-P.* “Fluorescent Molecular Rotors for Viscosity Sensors”, Chem. Eur. J. 2018, 24, 13706-13718. (selected as Front Cover)
Kim, H. J.*; Seo, Y. H.; Kim, H.; An, S.; Jo, A.;Kwon, I. C.; Kim, S.* “Chemiluminescence Imaging of Duox2-Derived Hydrogen Peroxide for Longitudinal Visualization of Biological Response to Viral Infection in Nasal Mucosa”, Theranostics 2018, 8, 1798-1807.
Lee, D.; Jeong, K.; Kim, G.; Yang, Y.; Chen, X.*; Kim, S.*; Yoon, J.* “Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse”, J. Mater. Chem. B. 2018, 6, 2541-2546.
Lee, S.-C.; Lee, C.-L.*; Heo, J.; Jeong, C.-U.; Lee, G.-H.; Kim, S.*; Yun, H.; Park, S. O.; Kwak, S. K.; Kwon, O.-P.* “Molecular Viscosity Sensors with Two Rotators for Optimizing the Fluorescence Intensity-Contrast Trade-off”, Chem. Eur. J. 2018, 24, 2888-2897. (selected as Front Cover)

2017

Kim, M.; Seo, Y. H.; Kim, Y.; Heo, J.; Jang, W.-D.; Sim, S. J.; Kim, S.* “A fluorogenic molecular nanoprobe with engineered internal environment for sensitive and selective detection of biological hydrogen sulfide”, Chem. Commun. 2017, 53, 2275.
Eom, T.; Yoo, W.; Lee, Y.-D.; Park, J. H.; Choe, Y.; Bang, J.; Kim, S.*; Khan, A.* “Activatable anticancer polymer-drug conjugate based on the self- immolative azobenzene motif”, J. Mater. Chem. B. 2017, 5, 4574-4578.
Choi, E.; Kim, S.* “How Can Doxorubicin Loading Orchestrate In Vitro Degradation Behaviors of Mesoporous Silica Nanoparticles in a Physiological Condition?”, Langmuir 2017, 33, 4974-4980.

2016

Singh, A.; Kim, W.; Kim, Y.; Jeong, K.; Kang, C. S.; Kim, Y. S.; Koh, J.; Mahajan, S. D.; Prasad, P. N.*; Kim, S.* “Multifunctional Photonics Nanoparticles for Crossing the Blood-BrainBarrier and Effecting Optically Trackable Brain Theranostics”, Adv. Funct. Mater. 2016, 26, 7057. (selected as Front Cover).
Cho, H.-J.; Lee, S.-J.; Park, S.; Paik, C. H.; Lee, S.-M.*; Kim, S.*; Lee, Y.-S.* “Activatable iRGD-based peptide monolith: targeting, internalization, and fluorescence activation for precise tumor imaging”, J. Control. Release 2016, 237, 177.
Seo, Y.; Singh, A.; Cho, H.-J.; Kim, Y.; Heo, J.; Lim, C.-K.; Park, S. Y.; Jang, W.-D.; Kim, S.* “Rational Design for Enhancing Inflammation-Responsive In Vivo Chemiluminescence via Nanophotonic Energy Relay to Near-Infrared AIE-Active Conjugated Polymer”, Biomaterials 2016, 84, 111.
Heo, J.; Lim, C.-K.; Kim, Y.; Cho, H.-J.; Lee, Y.-D.; Maeng, J.-h.; Ahn, D.-R.; Lee, S.; Bang, J.; Park, S. Y.*; Kim, S.* “Fluorogenic nanoreactor assembly with boosted sensing kinetics for timely imaging of cellular hydrogen peroxide”, Chem. Commun. 2016, 52, 1131 (Outside backcover).

2015

Singh, A.; Seo, Y.; Lim, C.-K.; Koh, J.*; Jang, W.-D.; Kwon, I. C.; Kim, S.* “Biolighted Nanotorch Capable of Systemic Self-Delivery and Diagnostic Imaging”, ACS Nano 2015, 9, 9906.
Lee, Y.-D.; Cho, H.-J.; Choi, M.-H.; Park, H.; Bang, J.; Lee, S.; Kwon, I. C.; Kim, S.* “Directed molecular assembly into a biocompatible photosensitizing nanocomplex for locoregional photodynamic therapy”, J. Control. Release 2015, 209, 12.
Li, Y.; Heo, J.; Lim, C.-K.; Pliss, A.; Kachynski, A.; Kuzmin, A. Kim, S.*; Prasad, P. N.* “Organelle specific imaging in live cells and immuno-labeling using resonance Raman probe”, Biomaterials 2015, 53, 25.
Seo, Y.; Cho, M. J.; Cheong, O. J.; Jang, W.-D.; Ohulchanskyy, T. Y.; Lee, S.; Choi, D. H.; Prasad, P. N.; Kim, S.* “Low-Bandgap Biophotonic Nanoblend: A Platform for Systemic Disease Targeting and Functional Imaging”, Biomaterials 2015, 39, 225.

2013

Jeong, K.; Park, S.; Lee, Y.-D.; Lim, C.-K.; Kim, J.; Chung, B. H.; Kwon, I. C.; Park, C. R.*; Kim, S.* “Conjugated Polymer/Photochromophore Binary Nanococktails: Bistable Photoswitching of Near-Infrared Fluorescence for In Vivo Imaging”, Adv. Mater. 2013, 25, 5574 (selected as Front Cover).
Shin, S.; Gihm, S. H.; Park, C. R.; Kim, S.*; Park, S. Y.* “Water-Soluble Fluorinated and PEGylated Cyanostilbene Derivative: An Amphiphilic Building Block Forming Self-Assembled Organic Nanorods with Enhanced Fluorescence Emission”, Chem. Mater. 2013, 25, 3288.
Singh, A.; Lim, C.-K.; Lee, Y.-D.; Maeng, J.-h.; Lee, S.; Koh, J.*; Kim, S.* “Tuning Solid-State Fluorescence to the Near-Infrared: A Combinatorial Approach to Discovering Molecular Nanoprobes for Biomedical Imaging”, ACS Appl. Mater. Interfaces 2013, 5, 8881 (selected as Front Cover).
Lim, C.-K.; Singh, A.; Heo, J.; Kim, D.; Lee, K. E.; Jeon, H.; Koh, J.; Kwon, I. C.; Kim, S.* “Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging”, Biomaterials 2013, 34, 6846.
Kim, K.-R.; Lee, Y.-D.; Lee, T.; Kim, B.-S.; Kim, S.*; Ahn, D.-R.* “Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron”, Biomaterials 2013, 34, 5226.

2012

Lee, Y.-D.; Lim, C.-K.; Singh, A.; Koh, J.; Kim, J.; Kwon, I. C.; Kim, S.* “Dye/Peroxalate Aggregated Nanoparticles with Enhanced and Tunable Chemiluminescence for Biomedical Imaging of Hydrogen Peroxide”, ACS Nano 2012, 6, 6759.
Lim, C.-K.; Shin, J.; Lee, Y.-D.; Kim, J.; Oh, K. S.; Yuk, S. H.; Jeong, S. Y.; Kwon, I. C.; Kim, S.* “Phthalocyanine-Aggregated Polymeric Nanoparticles as Tumor-Homing Near-Infrared Absorbers for Photothermal Therapy of Cancer”, Theranostics 2012, 2, 871.

2011

Lim, C.-K.; Shin, J.; Lee, Y.-D.; Kim, J.; Park, H.; Kwon, I. C.; Kim, S.* “Heavy-Atomic Construction of Photosensitizer Nanoformulation for Enhanced Photodynamic Therapy of Cancer”, Small 2011, 7, 112.

2010

Lim, C.-K.; Lee, Y.-D.; Na, J.; Oh, J. M.; Her, S.; Kim, K.; Choi, K.; Kim, S.*; Kwon, I. C. “Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide”, Adv. Funct. Mater. 2010, 20, 2644. (selected as Frontispiece Cover)
Lee, Y.-D.; Lim, C.-K.; Kim, S.*; Kwon, I. C.; Kim, J. “Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Bioimaging”, Adv. Funct. Mater. 2010, 20, 2786.
Kim, S.*; Lim, C.-K.; Na, J.; Lee, Y.-D.; Kim, K.; Choi, K.; Leary, J. F.; Kwon, I. C. “Conjugated polymer nanoparticles for biomedical in vivo imaging”, Chem. Commun. 2010, 46, 1617. (selected as Front Cover)