교수진
지성욱
- 직위 교수
- TEL 02-3290-3403
- Fax
- E-mail chi13@korea.ac.kr
- Office 하나과학관 A605
- 연구실 분자정보유전체학 연구실
세부전공
- RNA분자의과학, 유전체학, 생물정보학
학력
- 2003 ~ 2010미국 Rockefeller Univ., Ph.D. / Computational Biology and Medicine
- 1999 ~ 2001고려대학교 생명공학원 이학석사
- 1995 ~ 1999고려대학교 생명과학부 이학사
경력
- 2021 ~ 현재고려대학교 KU-KIST 융합대학원 학연교수
- 2021 ~ 고려대학교 생명과학대학 생명과학부 교수
- 2016 ~ 2021고려대학교 생명과학대학 생명과학부 부교수
- 2015 ~ 2016고려대학교 생명과학대학 생명과학부 조교수
- 2011 ~ 2015성균관대학교 삼성융합의과학원 조교수
- 2011 ~ 2015삼성서울병원 미래의학연구원 조교수
- 2010 ~ 2011미국 Cold Spring Harbor Laboratory, RNAI Research Center, Post-doc
- 2009 ~ 2010미국 Rockefeller Univ., Molecular Neuro-oncology Lab, Post-doc
- 2002 ~ 2003서울대학교 생물정보연구센터 연구원
- 2001 ~ 2002고려대학교 세포사멸연구센터 연구원
등록학회
- 한국분자세포생물학회
- 한국생명정보학회
수상
- [국내]2021
석탑연구상 (고려대학교)
- [국내]2021
한성과학상 생명과학부문 (한성 손재한 장학회)
- [국내]2020
한국분자세포생물학회 Blue Ribbon Lecture 수상자
주요논문
2023
더보기
- Eom S*, Peak J*, Park J*, Ahn SH*, Cho YK, Jeong Y, Lee HS, Lee J, Ignatova E, Lee SE, Hong Y, Gu D, Kim GWD, Lee DC, Hahm JY, Jeong J, Choi D, Jang ES, Chi SW (2023) Widespread 8-oxoguanine modifications of miRNA seeds alternately regulate redox-dependent cancer development Nature Cell Biology. (accepted)
- Hahm JY*, Park J*, Jang ES, Chi SW (2022) 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification Exp Mol Med. 54, 626–1642
- Ahn SH*, Gu D*, Koh Y, Lee HS, Chi SW (2021) AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity Scientific Reports 11, 19161
- Choi S, Choi D, Lee Y, Ahn SH, Seong JK, Chi SW, Oh TJ, Choi SH, Koo SH (2021) Depletion of Prmt1 in adipocytes impairs glucose homeostasis in diet-induced obesity. Diabetes 70(8):1664-1678.
- Gu D*, Ahn SH*, Eom S*, Lee HS, Ham J, Lee DH, Cho YK, Koh Y, Ignatova E, Jang ES, Chi SW (2021). "AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity" Molecular Therapy: Nucleic Acid, doi.org/10.1016/j.omtn.2021.01.018
- Choi S, Choi D, Lee Y, Ahn SH, Seong JK, Chi SW, Oh TJ, Choi SH, Koo SH (2021) Depletion of Prmt1 in adipocytes impairs glucose homeostasis in diet-induced obesity. Diabetes May; db201050.
- Seok H, Lee H, Lee S, Ahn SH, Lee HS, Kim GWD, Peak J, Park J, Cho YK, Jeong Y, Gu D, Jeong Y, Eom S, Jang ES, Chi SW (2020). "Position-specific oxidation of miR-1 encodes cardiac hypertrophy" Nature. 584, 279–285
- Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y (2020) "The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling" Proc Natl Acad Sci U S A 117(27), 15955-5966
- Park S*, Ahn SH*, Cho ES*, Cho YK, Jang ES, Chi SW (2018) "CLIPick: a sensitive peak caller for expression-based deconvolution of HITS-CLIP signals" Nucleic Acids Research 46(21):11153-11168
- Park J*, Ahn SH*, Cho KM*, Gu D, Jang ES, Chi SW (2018) "siAbasic: a comprehensive database for potent siRNA-6Ø sequences without off-target effects" Database 2018: bay109
- Seok H*, Lee H*, Jang ES, Chi SW (2018) "Evaluation and control of miRNA-like off-target repression for RNA interference" Cell Mol Life Sci 75: 797
- Seok H, Ham J, Jang ES, Chi SW (2016) "MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions" Mol Cells 31;39(5):375-81
- Seok H, Jang ES, Chi SW (2016) "Rationally designed siRNAs without miRNA-like off-target repression" BMB Rep. 49(3):135-6
- Lee HS*, Seok H*, Lee DH*, Ham J*, Lee W, Youm EM, Yoo JS, Lee YS, Jang ES, Chi SW (2015) "Abasic pivot substitution harnesses target specificity of RNA interference" Nature Communications 6:10154
- Choe J, Ryu I, Park OH, Park J, Cho H, Yoo JS, Chi SW, Kim MK, Song HK, Kim YK (2014) "eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5`UTR" Proc Natl Acad Sci U S A 111(43):E4577-86
- Kim YJ, Ku SY, Kim YY, Liu HC, Chi SW, Kim SH, Choi YM, Kim JG, Moon SY (2013) "MicroRNAs transfected into granulosa cells may regulate oocyte meiotic competence during in vitro maturation of mouse follicles" Human Reproduction 28(11):3050-61
- Kim KK, Ham J, Chi SW (2013) "miRTCat: a comprehensive map of human and mouse microRNA target sites including non-canonical nucleation bulges" Bioinformatics 29(15):1898-9
- Chi SW*, Hannon GJ and Darnell RB* (2012) "An alternative mode of microRNA target recognition" Nature Structural and Molecular Biology 19: 321-327.
- Darnell JC, Van Driesche S, Zhang C, Hung KYS, Aldo M, Fraser CE, Stone EF, Chen C, Fak J, Chi SW, Licatalosi D, Richter JD and Darnell RB (2011) "FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism" Cell 2011, 146 (2): 247-61
- Kim YJ, Ku SY, Rosenwaks Z, Liu HC, Chi SW, Kang JS, Lee WJ, Jung KC, Kim SH, Choi YM, Kim JG, Moon SY (2010) "MicroRNA Expression Profiles are Altered by Gonadotropins and Vitamin C Status During In Vitro Follicular Growth" Reproductive Sciences vol. 17 no. 12 1081-1089.
- Chi SW, Zang JB, Mele A, Darnell RB (2009) "Argonaute HITS-CLIP decodes miRNA-mRNA interaction maps" Nature 460 (7254): 479-86
- Licatalosi DD, Mele A, Fak JJ, Ule J, Kayikci M, Chi SW, Clark TA, Schweitzer AC, Blume JE, Wang X, Darnell JC, Darnell RB (2008) "HITS-CLIP yields genome-wide insights into brain alternative RNA processing" Nature 456 (7221): 464-9.
특허
2022
더보기
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Chi SW, Jang ES (2022) Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof. IP Canada
[등록번호]CA2933171
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Chi SW, Jang ES, Seok H (2022) Modified nucleic acid inhibiting microRNA, and use thereof. IP Japan
[등록번호]7162918
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Chi SW, Jang ES (2021) "Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof" (중국)
[등록번호]CN105829535B
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Chi SW, Jang ES (2020) "Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof" (일본)
[등록번호]6748687 -
Chi SW, Jang ES (2020) "Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof" (유럽)
[등록번호]EP3085784B1 -
지성욱, 장은숙, 석희영 (2020) 마이크로RNA를 억제하는 변형 핵산 및 이의 용도
[등록번호]10-2193874 -
지성욱, 장은숙, 석희영 (2020) 마이크로RNA의 비정규 표적을 억제하는 RNA 간섭 유도 핵산 및 그 용도
[등록번호]10-2193873 -
지성욱, 장은숙, 석희영 (2020) 마이크로RNA의 비정규 표적을 억제하는 RNA 간섭 유도 핵산 및 그 용도
[등록번호]10-2193869 -
지성욱, 장은숙, 석희영 (2020) 마이크로RNA의 비정규 표적을 억제하는 RNA 간섭 유도 핵산 및 그 용도
[등록번호]10-2193864 -
지성욱, 장은숙 (2020) RNA 간섭 유도 핵산 및 이를 포함하는 HPV 감염 유발 암의 치료용 약학 조성물
[등록번호]10-2129852
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Chi SW, Jang ES (2019) "Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof" (미국)
[등록번호]US10227592 B2 -
지성욱, 장은숙, 석희영 (2019) 마이크로RNA의 비정규 표적을 억제하는 RNA 간섭 유도 핵산 및 그 용도.
[등록번호]10-2012943
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Chi SW, Jang ES (2018) "Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof" (호주)
[등록번호]2014367550
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지성욱, 장은숙 (2017) 오프-타겟을 막기 위해 변형된 RNA 간섭 유도 핵산 및 그 용도.
[등록번호]10-1696704
