TOP
공동기기
KUPID

교수진

김인산

  • 직위 객원교수
  • TEL 02-3290-4614|02-958-5935
  • Fax 02-958-5909
  • E-mail iskim14@kist.re.kr
  • Office 고려대학교 KU R&D센터 4층 433호,(KIST L1124)

세부전공

  • Molecular mechanisms of cell-cell fusion
  • Apoptotic cell recognition and clearance
  • Protein nangocages for nanomedicine
  • Exosome engineering
  • Anticancer drug development

학력

  • 1986 ~ 1989D. Med. Sci (Ph.D) Biochemistry, Kyungpook National University
  • 1984 ~ 1986M. Med. Sci (MS) Biochemistry, Kyungpook National University
  • 1978 ~ 1984B. Med (MD) in School of Medicine Kyungpook National University

경력

  • 2014 ~ Principal research scientist, Korea Institute Science & Technology
  • 2012 ~ Health Technology Policy Committee, Ministry of Health & Welfare
  • 2011 ~ Advisory board, Korea National Institute of Health
  • 2011 ~ Bio-Health division, National Science & Technology Commission
  • 2010 ~ 2011Director, KNU Industry-Academic Cooperation Foundation & Research Affair
  • 1996 ~ 1997Visiting assistant professor, University of Texas M. D. Anderson Cancer Center
  • 1994 ~ 1996Research Associate, University of Texas M. D. Anderson Cancer Center
  • 1993 ~ 1993Research fellowship, Department of Dermatology, Jefferson Medical College
  • 1989 ~ 2014Professor, School of Medicine, Kyungpook National University
더보기

수상

  • [국내]2015

    Service Merit Medal Korea Government

  • [국내]2014

    KNU Industry-Academic Cooperation Award

  • [국내]2012

    Award by National Science & Technology Commission

  • [국내]2010

    Wunsch Medical Award

  • [국내]2008

    KSMBMB achievementaward

  • [국내]2007

    KNU Wonam Award

더보기

주요논문

2017
  • Koh E, Lee EJ, Nam GH, Hong Y, Cho E, Yang Y, Kim IS. Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis. Biomaterials. 2017 Mar;121:121-129.
  • Yang Y, Hong Y, Nam GH, Chung JH, Koh E, Kim IS. Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes. Adv Mater. 2017 Apr;29(13).
  • Yeonsun Hong, Gi‐Hoon Nam, Eunee Koh, Sangmin Jeon, Gi Beom Kim, Cherlhyun Jeong, Dong‐Hwee Kim, Yoosoo Yang, In‐San Kim. Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy. Adv Func Mater. 2017 Dec
2016
  • Park SY, Yun Y, Lim JS, Kim MJ, Kim SY, Kim JE, Kim IS. Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration. Nat Commun. 2016 Mar 14;7:10871.
  • Al-Hilal TA, Chung SW, Choi JU, Alam F, Park J, Kim SW, Kim SY, Ahsan F, Kim IS, Byun Y. Targeting prion-like protein doppel selectively suppresses tumor angiogenesis. J Clin Invest. 2016 Apr 1;126(4):1251-66.
  • Lee EJ, Lee NK, Kim IS. Bioengineered protein-based nanocage for drug delivery. Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):157-171.
2015
  • Wonhwa Lee, Junyoung Seo, Soyoung Kwak, Eun Ji Park, Dong Hee Na, Soyoun Kim, You Mie Lee, In-San Kim*,and Jong-SupBae* A double-chambered protein nanocage loaded with thrombin receptor agonist peptide (TRAP) and γ-carboxyglutamic acid of protein C (PC-Gla) for sepsis treatment. Advanced Materials in press *co-corresponding
  • Lee GY, Kim JH, Choi KY, Yoon HY, Kim K, Kwon IC, Choi K, Lee BH, Park JH, Kim IS. Hyaluronic Acid Nanoparticles for Active Targeting Atherosclerosis Biomaterials. 2015 Jun;53:341-8.
2014
  • Bae JS, Lee W, Son HN, Lee YM, Kim IS. Anti-TGFBIp antibody ameliorates vascular barrier dysfunction and improves survival in sepsis. Acta Physiol (Oxf). 2014 212(4):306-15
  • Jong-Sup Bae, Wonhwa Lee, Ju-Ock Nam, Jung-Eun Kim, Shin-Woo Kim and In-San Kim, Transforming growth factor β-induced protein promotes severe vascular inflammatory responses, American Journal of Respiratory and Critical Care Medicine, 2014 Apr 1;189(7):779-86
  • Cho YW, Kim SY, Kwon IC, Kim IS. Complex adaptive therapeutic strategy (CATS) for cancer. J Control Release. 2014 Feb 10;175:43-7.
2013
  • Jeon JO, Kim S, Choi E, Shin K, Cha K, So IS, Kim SJ, Jun E, Kim D, Ahn HJ, Lee BH, Lee SH, Kim IS. A Designed Nanocage Displaying Ligand-Specific Peptide Bunches for High Affinity and Biological Activity. ACS Nano. 2013 Sep 24;7(9):7462-71.
  • Son HN, Nam JO, Kim S, Kim IS. Multiple FAS1 domains and the RGD motif of TGFBI act cooperatively to bind αvβ3 integrin, leading to anti-angiogenic and anti-tumor effects. Biochim Biophys Act-Molecular Cell Research. 2013 Oct;1833(10):2378-88.
  • Kim W, Kim SY, Kim T, Kim M, Bae DJ, Choi HI, Kim IS, Jho E. ADP-ribosylation factors 1 and 6 regulate Wnt/β-catenin signaling via control of LRP6 phosphorylation. Oncogene. 2013 Jul 11;32(28):3390-6.*co-corresponding
2012
  • Nam JO, Son HN, Jun E, Cha K, Lee BH, Park RW, Kim IS. FAS1-domain protein inhibits VEGF165-induced angiogenesis by targeting the interaction between VEGFR-2 and αvβ3 integrin. Mol Cancer Res. 2012 Aug;10(8):1010-20.
  • Kim S, Park SY, Kim SY, Bae DJ, Pyo JH, Hong M, Kim IS. Cross-talk between engulfment receptors, stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine exposed erythrocytes, Mol Cell Biol. 2012 Jul;32(14):2698-708.
  • Park SY, Bae DJ, Kim MJ, Piao ML, Kim IS. Extracellular low pH modulates phosphatidylserine-dependent phagocytosis in macrophages by increasing stabilin-1 expression. J Biol Chem. 2012 Mar 30;287(14):11261-71.
  • Kim JH, Bae SM, Na MH, Shin H, Yang YJ, Min KH, Choi KY, Kim K, Park RW, Kwon IC, Lee BH, Hoffman AS, Kim IS. Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues. J Control Release. 2012 Feb 10;157(3):493-9.
2011
  • Lee GY, Kim JH, Oh GT, Lee BH, Kwon IC, Kim IS. Molecular targeting of atherosclerotic plaques by a stabilin-2-specific peptide ligand. J Control Release. 2011 Oct 30;155(2):211-7.
  • Wang K, Na MH, Hoffman AS, Shim G, Han SE, Oh YK, Kwon IC, Kim IS, Lee BH. In situ dose amplification by apoptosis-targeted drug delivery. J Control Release. 2011 Sep 25;154(3):214-7. *co-corresponding
  • Lee SJ, Park SY, Jung MY, Bae SM, Kim IS. Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver. Blood. 2011 May 12;117(19):5215-23.
2010
  • Wang K, Pruthodam S, Lee JY, Na MH, Park H, Oh SJ, Park RW, Park JY, Lee EB, Cho BC, Song MN, Baek MC, Kwak W, Yoo J, Hoffman AS, Oh YK, Kim IS, Lee BH. In vivo imaging of tumor apoptosis using histone H1-targeting peptide. J Control Release. 2010 Dec 20;148(3):283-91. *co-corresponding
  • Kim S, Bae DJ, Hong M, Park SY, Kim IS. The conserved histidine in Epidermal Growth Factor-like domains of Stabilin-2 modulates pH dependent recognition of phosphatidylserine in apoptotic cells. Int J Biochem Cell Biol. 2010 Jul;42(7):1154-63.
2009
  • Park SY, Jung MY, Lee SJ, Kang KB, Gratchev A, Riabov V, Kzhyshkowska J, Kim IS. Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J Cell Sci. 2009 Sep 15;122(Pt 18):3365-73.
  • Ha-Jeong Kim, Pan-Kyung Kim, Sang Mun Bae, Hye-Nam Son, Thoudam Debraj Singh, Jung-Eun Kim, Byung-Heon Lee, Rang-Woon Park, In-San Kim, Transforming growth factor-beta-induced protein (TGFBIp/beta ig-h3) activates platelets and promotes thrombogenesis. Blood. 2009 Dec 10;114(25):5206-15.
더보기