논문
Engulfment signals and the phagocytic machinery for apoptotic cell clearance
구분 : International Journal 저자 : Park SY, Kim IS 게재년월 : 2017.05 게재지 : EXPERIMENTAL AND MOLECULAR MEDICINE
The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as ‘find-me’ and ‘eat-me’ signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment.
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