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Professor Dong-Hwee Kim’s team makes breakthrough in mechanobiology of immunity
2022.11.07 Views 423
Professor Dong-Hwee Kim’s team makes breakthrough in mechanobiology of immunity

“Here, we demonstrate that when immune cells are exposed to varying micro-environmental settings, the nuclear transport of transcription factors regulates M2 specific immune activity,” announced Kim’s Team in the summary of their paper.

The team’s paper was published on the cover of the internationally renowned academic biology journal, Biomaterials, on November 11. The paper is named “Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophages”. In this research the team analyzed the structural alteration of macrophages in response to changes of substrate rigidity, which is followed by analysis of gene expression profiling.
The cutting edge results presented in the paper are expected to advance research in various medical fields, such as cancer treatments and regenerative tissue modeling.
Professor Kim commented that “the paradigm shift in understanding biological phenomenon by employing approaches from Physics can help solve the current conundrums in biology. Furthermore, this finding is expected to identify the cell-level treatment for curing diseases that trouble mankind.”

