Research
Articles
Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes
Category : International Journal Editor : Yang Y, Hong Y, Nam GH, Chung JH, Koh E, Kim IS Published Date : 2017.04 Publications : ADVANCED MATERIALS
An efficient system for direct delivery of integral membrane proteins is successfully developed using a new biocompatible exosome-based platform. Fusogenic exosomes harboring viral fusogen, vascular stomatitis virus (VSV)-G protein, can fuse with and modify plasma membranes in a process called “membrane editing.” This can facilitate the transfer of biologically active membrane proteins into the target cell membranes both in vitro and in vivo.
